Epigenetics and Your Health |
Epigenetics: The Death of the Genetic Theory of Disease Transmission WHAT IS EPIGENETICS?
Epigenetics is an emerging field of
science that studies alterations in gene expression caused
by factors other than changes in the DNA sequence.
Epigenetics: The Death of the Genetic Theory of Disease
Transmission is the result of decades of research and its
findings that could be as critical to our understanding of
human health as Pasteur’s research in
bacteriology. Dr. Joel “Doc” Wallach has dedicated his
life work to identifying connections between certain
nutritional deficiencies and a range of maladies, formerly
thought to be hereditary, including Cystic Fibrosis and
Muscular Dystrophy. This nexus between nutrition and
so-called genetic disease has been observed in both humans
and primates, and it is the central theme of Epigenetics.
To bring us Epigenetics, Wallach has teamed with noted
scholars Dr. Ma Lan and Dr. Gerhard N. Schrauzer. Their
collective expertise gives this book its far reaching
perspective. Epigenetics is of vital importance to anyone
who wants real knowledge about how the human body
functions, and it provides a path for better health.
Epigentics dispels the dogma and misinformation propagated
by medical institutions and doctors resistant to change. Epigenetics
is the beginning of a new era of well-being on this
planet.
In many biological
processes the regulation of gene expression involves epigenetic
mechanisms. In this new edition of Epigenetics, 36
chapters written by experts in the field introduce and
explain epigenetic effects from many
perspectives. These include the varied molecular
mechanisms underpinning epigenetic regulation,
discussion of cellular processes that rely on this kind
of regulation, and surveys of model organisms in which
epigenetic effects have been most studied.
The original chapters have all been rewritten and brand new chapters cover topics such as the structure, function, and dynamics of histone-modifying enzymes and histone-interacting proteins. Other chapters address chromatin remodeling, DNA methylation, siRNAs, and gene silencing; X-chromosome inactivation, dosage compensation, and imprinting; and epigenetics in microbes, plants, insects, and mammals. How epigenetic mechanisms act in cell division and cell type specification, and how errors in these pathways contribute to cancer and other human diseases are also considered, along with the importance of epigenetics for induced pluripotency and reprogramming. In addition, new chapters describe the involvement of epigenetic processes in epigenetic inheritance, neuronal development, metabolism and signaling, responses to the environment, and long-range chromatin interactions. A series of short essays highlight important recent discoveries. All the chapters provide conceptual illustrations that help readers understand epigenetic control. The book is thus a benchmark text for advanced undergraduate and graduate courses on gene regulation, as well as an essential resource for scientists interested in this rapidly moving field. Epigenetics
can potentially revolutionize our understanding of the
structure and behavior of biological life on Earth. It
explains why mapping an organism's genetic code is not
enough to determine how it develops or acts and shows
how nurture combines with nature to engineer biological
diversity. Surveying the twenty-year history of the
field while also highlighting its latest findings and
innovations, this volume provides a readily
understandable introduction to the foundations of epigenetics.
Nessa Carey, a leading epigenetics researcher, connects the field's arguments to such diverse phenomena as how ants and queen bees control their colonies; why tortoiseshell cats are always female; why some plants need cold weather before they can flower; and how our bodies age and develop disease. Reaching beyond biology, epigenetics now informs work on drug addiction, the long-term effects of famine, and the physical and psychological consequences of childhood trauma. Carey concludes with a discussion of the future directions for this research and its ability to improve human health and well-being. Change Your Genes, Change Your Life: Creating Optimal Health with the New Science of Epigenetics Our biology is no longer
destiny. Our genes respond to everything we do,
according to the revolutionary new science of epigenetics.
In other words, our inherited DNA
doesn't rigidly determine our health and disease
prospects as the previous generation of geneticists
believed. Especially in the last ten years, scientists
have confirmed that the vast majority of our genes are
actually fluid and dynamic. An endless supply of new
studies prove that our health is an expression of how we
live our lives--that what we eat and think and how we
handle daily stress, plus the toxicity of our immediate
environment--creates an internal biochemistry that can
actually turn genes on or off. Managing these
biochemical effects on our genome is the new key to
radiant wellness and healthy longevity.
Now gaining broad credibility among scientists, the study of epigenetics is at the forefront of modern medicine. According to the author, the real upshot of the epigenetic revolution is that it opens the door to what futurists call personalized medicine. For the first time in a trade book, Dr. Pelletier explains in layperson's language the genetic biomarkers that will become the standard reference for measuring which specific lifestyle changes are required to optimize a given individual's health. In the very near future, each person's state-of-the-art genetic and epigenetic profile--matched with other precise indicators such as assays of the gut microbiome--will guide their daily health practices. This short but profound book by a world-renowned pioneer in integrative medicine introduces readers to this exciting new field, and reveals the steps that each of us can take today to change our genetic expression and thereby optimize our health for a lifetime. Epigenetics is the study
of heritable changes in gene function that do not
involve changes in the DNA sequence. These changes,
consisting principally of DNA methylation, histone
modifications, and non-coding RNAs, maintain or modulate
the initial impact of regulatory factors that recognize
and associate with particular genomic sequences. Epigenetic
modifications are manifest in all aspects of
normal cellular differentiation and function, but they
can also have damaging effects that result in
pathologies such as cancer. Research is continuously
uncovering the role of epigenetics in a variety of human
disorders, providing new avenues for therapeutic
interventions and advances in regenerative medicine.
This book's primary goal is to establish a framework
that can be used to understand the basis of epigenetic
regulation and to appreciate both its derivation from
genetics and interdependence with genetic mechanisms. A
further aim is to highlight the role played by the
three-dimensional organization of the genetic material
itself (the complex of DNA, histones and non-histone
proteins referred to as chromatin), and its distribution
within a functionally compartmentalized nucleus. This
architectural organization of the genome plays a major
role in the subsequent retrieval, interpretation, and
execution of both genetic and epigenetic
information.
Handbook of Epigenetics: The New Molecular and Medical Genetics 2nd Edition Handbook of Epigenetics:
The New Molecular and Medical Genetics, Second Edition,
provides a comprehensive analysis of epigenetics, from
basic biology, to clinical application. Epigenetics is
considered by many to be the new genetics in that many
biological phenomena are controlled, not through gene
mutations, but rather through reversible and heritable
epigenetic processes. These epigenetic processes
range from DNA methylation to prions. The biological
processes impacted by epigenetics are vast and encompass
effects in lower organisms and humans that include
tissue and organ regeneration, X-chromosome
inactivation, stem cell differentiation, genomic
imprinting, and aging.
The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials Your Body is a Self-Healing Machine Book 3: Understanding How Epigenetics Heals You This third book in the trilogy of Your
Body Is A Self-Healing Machine explains the basics of applied
epigenetics and its practical use. It is in
this book Your Body is a Self-Healing Machine:
Understanding How Epigenetics Heals You
where you will learn how you can reprogram epigenetics
information to influence your gene
expression. Your decisions, either big or small, on each
factor, will positively or negatively update or
downgrade your epigenome. What you feel, think, eat,
breathe, drink, sleep, sun exposure, detox, fast and
pray are all epigenetic information that tweaks your
gene expression on or off.
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