:
Interactive Effects on Nutrition and Health focuses on the
fascinating
as it
relates to nutrition. The book covers the core science in
the microbiome field and draws links between the
microbiome and nutrition in medicine. Reflecting the most
current state of evidence available in the field, the
early chapters introduce key concepts about the
microbiome, and the latter focus on the application of the
and nutrition science.
Both human studies and animal studies (where appropriate)
are discussed throughout the work.
Addressing topics such as gut microbiota throughout the
lifespan,
in health and
disease, and genetic and environmental influences on gut
microbiota, this book will provide scientists and
clinicians who have an interest in the microbiome with an
understanding of the future potential and limitations of
this tool as they strive to make use of evidence-based
diet information for the maintenance of good health.
You are just 10% human.
For every one of the cells that make up the vessel that
you call your body, there are nine impostor cells
hitching a ride. You are not just flesh and blood,
muscle and bone, brain and skin, but also
bacteria and fungi. Over your lifetime, you
will carry the equivalent weight of five African
elephants in microbes. You are not an individual but a
colony.
Until recently, we had thought our microbes hardly
mattered, but science is revealing a different story,
one in which
microbes run our bodies
and becoming a healthy human is impossible without them.
In this riveting, shocking, and beautifully written
book, biologist Alanna Collen draws on the latest
scientific research to show how our personal colony of
microbes influences our weight, our immune system, our
mental health, and even our choice of partner. She
argues that so many of our modern diseases—obesity,
autism, mental illness, digestive disorders, allergies,
autoimmunity afflictions, and even cancer—have their
root in our failure to cherish our most fundamental and
enduring relationship: that with our personal
colony
of microbes.
The good news is that unlike our human cells, we can
change our microbes for the better. Collen’s book is a
revelatory and indispensable guide. Life—and your
body—will never seem the same again.
The
Mind-Gut Connection: How the Hidden Conversation
Within Our Bodies Impacts Our Mood, Our Choices,
and Our Overall Health
Combining cutting-edge
neuroscience with the latest discoveries on the
human microbiome, a practical guide in the
tradition of Wheat Belly and Grain Brain that
conclusively demonstrates the inextricable, biological
link between mind and body.
We have all experienced the connection between our
mind and our gut—the decision we made because it “felt
right”; the butterflies in our stomach before a big
meeting; the anxious stomach rumbling when we’re
stressed out. While the dialogue between the gut and
the brain has been recognized by ancient healing
traditions, including Ayurvedic and Chinese medicine,
Western medicine has failed to appreciate the
complexity of how the brain, gut, and more recently,
the microbiome—the microorganisms that live inside
us—communicate with one another. In The Mind-Gut
Connection, Dr. Emeran Mayer, executive director of
the UCLA Center for Neurobiology of Stress, offers a
revolutionary look at this developing science,
teaching us how to harness the power of the mind-gut
connection to take charge of our health.
The Mind-Gut Connection shows how to keep the
brain-gut communication clear and balanced to:
• heal the gut by focusing on a
plant-based diet
• balance the microbiome by consuming fermented foods
and probiotics, fasting, and cutting out sugar and
processed foods
• promote weight loss by detoxifying and creating
healthy digestion and maximum nutrient
absorption
• boost immunity and prevent the onset of neurological
diseases such as Parkinson’s and Alzheimer’s
• generate a happier mindset and reduce fatigue,
moodiness, anxiety, and depression
• prevent and heal GI disorders such as leaky gut
syndrome, food sensitivities and allergies, and IBS,
as well as digestive discomfort such as heartburn and
bloating
• and much more.
Gut
Microbiota, Immunity, and Health in Production
Animals (The Microbiomes of Humans, Animals,
Plants, and the Environment, 4)
This work sheds new
light on the interplay between the
gut,
gut microbiota, and host
physiological processes in production animals.
The
gut microbiome shapes health and
susceptibility to disease and has become a leading
area of research in the animal sciences. Gut health
encompasses a number of physiological and functional
features. Nutrient digestion and absorption, host
metabolism and energy generation, a stable microbiome,
mucus layer development, barrier function, and mucosal
immune responses; all of which are required to
interact to make an animal perform physiologically and
according to its greatest genetic potential.
This carefully presented book broadens our vision,
approach and results on
gut health
and the ability to regulate animal production.
Understanding the chemistry of microbiomes has broad
implications, including providing functional
annotations for the microbial genomes, insights into
the chemical languages that link microbes to each
other and to their host, and translational
implications for precision veterinary medicine,
environmental health, and sustainable animal
agriculture and welfare. Experts working in microbiome
research, host immunity, and animal production,
veterinarians and researchers in livestock science
will understand the great importance of this volume.
Gut
Microbiota in Neurologic and Visceral Diseases
Gut
Microbiota in Neurologic and Visceral
Diseases presents readers with comprehensive
information on the involvement of
microbiota
in the pathogenesis of neurological
disorders. Chapters cover the effect of microbiota
on the development of visceral (obesity, type 2
diabetes, heart disease) and neurological disorders
(Alzheimer’s disease, Parkinson’s, depression,
anxiety, and autism). Sections focus on the
molecular mechanisms and signal transduction
processes associated with the links among
microbiota-related visceral and neurological
disorders. It is hoped that this discussion will not
only integrate and consolidate knowledge in this
field but will also jumpstart more studies on the
involvement of microbiota in the pathogenesis of
neurological disorders.
The
Human Microbiota and Chronic Disease:
Dysbiosis as a Cause of Human Pathology
Microbiota-associated
pathology can be a direct result of changes in
general bacterial composition, such as might be
found in periodontitis and bacterial vaginosis,
and/or as the result of colonization and/or
overgrowth of so called keystone species. The
disruption in the composition of the normal human
microbiota, or dysbiosis, plays an
integral role in human health and human disease.
The Human Microbiota and Human Chronic Disease:
Dysbioses as a Cause of Human Pathology discusses
the role of the microbiota in
maintaining human health. The text introduces the
reader to the biology of microbial dysbiosis and
its potential role in both bacterial disease and
in idiopathic chronic disease states.
Divided into five sections, the text delineates
the concept of the human bacterial
microbiota with particular attention
being paid to the microbiotae of the gut, oral
cavity and skin. A key methodology for exploring
the microbiota, metagenomics, is also described.
The book then shows the reader the cellular,
molecular and genetic complexities of the bacterial
microbiota, its myriad connections with
the host and how these can maintain tissue
homeostasis. Chapters then consider the role of
dysbioses in human disease states, dealing with
two of the commonest bacterial diseases of
humanity – periodontitis and bacterial vaginosis.
The composition of some, if not all microbiotas
can be controlled by the diet and this is also
dealt with in this section. The discussion moves
on to the major ‘idiopathic’ diseases afflicting
humans, and the potential role that dysbiosis
could play in their induction and chronicity. The
book then concludes with the therapeutic potential
of manipulating the microbiota, introducing the
concepts of probiotics, prebiotics and the
administration of healthy human faeces (faecal
microbiota transplantation), and then hypothesizes
as to the future of medical treatment viewed from
a microbiota-centric position.
Provides an introduction to dysbiosis, or a
disruption in the composition of the normal human
microbiota
Explains how microbiota-associated pathology and
other chronic diseases can result from changes in
general bacterial composition
Explores the relationship humans have with their
microbiota, and its significance in human health
and disease
Covers host genetic variants and their role in the
composition of human microbial biofilms, integral
to the relationship between human health and human
disease
Authored and edited by leaders in the field, The
Human Microbiota and Human Chronic Disease will be
an invaluable resource for clinicians,
pathologists, immunologists, cell and molecular
biologists, biochemists, and system biologists
studying cellular and molecular bases of human
diseases.
Microbial
Endocrinology: The Microbiota-Gut-Brain Axis in
Health and Disease (Advances in Experimental
Medicine and Biology, 817)
The field of microbial
endocrinology is expressly devoted to understanding
the mechanisms by which the microbiota (bacteria
within the microbiome) interact with the host (“us”).
This interaction is a two-way street and the driving
force that governs these interactions are the
neuroendocrine products of both the host and the
microbiota.
Chapters include neuroendocrine hormone-induced
changes in gene expression and microbial endocrinology
and probiotics. This is the first in a series of books
dedicated to understanding how bi-directional
communication between host and bacteria represents the
cutting edge of translational medical research, and
hopefully identifies new ways to understand the
mechanisms that determine health and disease.
Metabonomics
and Gut Microbiota in Nutrition and Disease
This book provides a
comprehensive overview of metabonomics
and gut microbiota research from
molecular analysis to population-based global health
considerations. The topics include the discussion of
the applications in relation to metabonomics and gut
microbiota in nutritional research, in
health and disease and a review of future
therapeutical, nutraceutical and clinical
applications. It also examines the translatability
of systems biology approaches into applied clinical
research and to patient health and
nutrition.
The rise in multifactorial disorders, the lack of
understanding of the molecular processes at play and
the needs for disease prediction in asymptomatic
conditions are some of the many questions that
system biology approaches are well suited to
address. Achieving this goal lies in our ability to
model and understand the complex web of interactions
between genetics, metabolism, environmental factors
and gut microbiota. Being the most densely populated
microbial ecosystem on earth, gut microbiota
co-evolved as a key component of human biology,
essentially extending the physiological definition
of humans.
Major advances in microbiome research have shown
that the contribution of the intestinal
microbiota to the overall health status
of the host has been so far underestimated. Human
host gut microbial interaction is one of the most
significant human health considerations of the
present day with relevance for both prevention of
disease via microbiota-oriented environmental
protection as well as strategies for new therapeutic
approaches using microbiota as targets and/or
biomarkers. In many aspects, humans are not a
complete and fully healthy organism without their
appropriate microbiological components.
Increasingly, scientific evidence identifies gut
microbiota as a key biological interface between
human genetics and environmental conditions
encompassing nutrition. Microbiota dysbiosis or
variation in metabolic activity has been associated
with metabolic deregulation (e.g. obesity,
inflammatory bowel disease), disease risk factor
(e.g. coronary heart disease) and even the aetiology
of various pathologies (e.g. autism, cancer),
although causal role into impaired metabolism still
needs to be established.
Metabonomics and Gut Microbiota in Nutrition and
Disease serves as a handbook for postgraduate
students, researchers in life sciences or health
sciences, scientists in academic and industrial
environments working in application areas as diverse
as health, disease, nutrition, microbial research
and human clinical medicine.
The
Human Microbiota and Microbiome
Thousands of different
microbial species colonize the human
body, and are essential for our survival. This book
presents a review of the current understanding of
human microbiomes, the functions that they bring to
the host, how we can model them, their role in health
and disease and the methods used to explore them.
Current research into areas such as the long-term
effect of antibiotics makes this a subject of
considerable interest. This title is essential reading
for researchers and students of microbiology.