Oxidative Stress Nutrition |
Nutrition and Epigenetics (Oxidative Stress and Disease) Nutrition and Epigenetics
presents new information on the action of diet and
nutritional determinants in regulating the epigenetic
control of gene expression in health and disease. Each
chapter gives a unique perspective on a different
nutritional or dietary component or group of components,
and reveals novel mechanisms by which dietary factors
modulate the epigenome and affect development processes,
chronic disease, and the aging process. This pivotal text:
Documents the epigenetic effect of antioxidants and their health benefits Adds to the understanding of mechanisms leading to disease susceptibility and healthy aging Illustrates that the epigenetic origins of disease occur in early (fetal) development Synthesizes the data regarding nutrient and epigenomic interactions Nutrition and Epigenetics highlights the interactions among nutrients, epigenetics, and health, providing an essential resource for scientists and clinical researchers interested in nutrition, aging, and metabolic diseases. About the Author Emily Ho is the endowed director of the Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health. She is a full professor in the College of Public Health and Human Sciences, with an emphasis in nutrition, and is a principal investigator at the Linus Pauling Institute at Oregon State University. She joined the Oregon State University faculty in 2003 after receiving her Ph.D in human nutrition from the Ohio State University and completing her postdoctoral research at Children’s Hospital Oakland Research Institute and UC Berkeley. During the course of her career, Dr. Ho has published 97 peer-reviewed articles and abstracts and four book chapters. She has been invited to give more than 40 presentations and has mentored more than 40 undergraduate and graduate students. She currently serves on the editorial board for Journal of Nutritional Biochemistry and Frontiers in Epigenomics. Her research interests are in the area of antioxidants and gene expression and dietary chemoprevention strategies. More specifically, she focuses on the effects of zinc status on DNA damage, DNA repair, and stress–response signal pathways. Another major focus in her laboratory is investigating the genetic and epigenetic mechanisms by which foods such as soy, tea, and cruciferous vegetables may protect against prostate cancer. Inflammation, Lifestyle and Chronic Diseases (Oxidative Stress and Disease) Oxidative stress
and inflammation are among the most important factors of
disease. Chronic infections, obesity, alcohol and
tobacco usage, radiation, environmental pollutants, and
high-calorie diets have been recognized as major risk
factors for a variety of chronic diseases from cancer to
metabolic diseases. All these risk factors are linked to
chronic diseases through inflammation. While short-term,
acute inflammation generated by the immune system serves
a therapeutic role, chronic low-level inflammation that
may persist "silently" for decades is responsible for
chronic diseases.
Inflammation, Lifestyle, and Chronic Diseases: The Silent Link describes the role of dysregulated inflammation in persistent and recurring diseases. It investigates links to lifestyle and presents research on how the suppression of proinflammatory pathways may provide opportunities for both prevention and treatment of chronic diseases. The book covers neurodegenerative diseases, pulmonary diseases, asthma, rheumatic and arthritic diseases, skin disease, heart disease, chronic wounds, infectious disease, neuropsychiatric disorders such as depression, gastrointestinal diseases, insulin resistance, and cancer, many of which are also diseases of old age. For each chronic disease, contributors review the clinical and scientific literature and examine current and potential therapies, including conventional pharmacotherapies as well as natural products. Noting that the long-term use of steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause adverse side effects, many of the chapters address the role of dietary agents such as fruits, vegetables, legumes, pulses, nuts, and spices as ideal anti-inflammatory agents that can be consumed regularly. The book also suggests directions for further research. Clinical and science researchers, students, and health professionals interested in the link between inflammation, lifestyle, and chronic diseases will find this an informative resource. Aging: Oxidative Stress and Dietary Antioxidants Aging: Oxidative
Stress and Dietary Antioxidants, Second
Edition, bridges the trans-disciplinary divide and
covers the science of oxidative stress in aging and the
therapeutic use of natural antioxidants in the food
matrix in a single volume. The second edition covers new
trials and investigations used to determine the
comprehensive properties of antioxidants, food items and
extracts, as well as any adverse properties they may
have. It has been updated to include new clinical human
trials and a new section dedicated to animal models of
aging. Throughtout the book the processes within the
science of oxidative stress are described in concert
with other processes, such as apoptosis, cell signaling,
and receptor mediated responses. This approach
recognizes that diseases are often multifactorial, and
oxidative stress is a single component of this.
Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. This will aid in better research, treatment and outcome for patients. Flavonoids and Related Compounds: Bioavailability and Function (Oxidative Stress and Disease) Flavonoids exert a
multiplicity of biological effects on humans and can
have beneficial implications for numerous disease
states. Flavonoids and Related Compounds:
Bioavailability and Function examines current knowledge
regarding the absorption, metabolism, and
bioavailability of individual flavonoids and related
phenolic compounds.
Profiling the latest evidence of their impact on various human pathological conditions, the book summarizes current thinking with regard to the biotransformation and conjugation of individual compounds in the gastrointestinal tract, liver, large intestine, and cells. It highlights a topic that has been largely ignored―namely the extent to which dietary phenolics components undergo metabolism in the large intestine. It also explores the generation of bacterially derived metabolites. Individual chapters discuss which metabolites enter the circulatory system and are likely to offer protective actions against human diseases. Edited by internationally recognized leaders in the field, the book presents contributions by a panel of experts who demonstrate the potential of flavonoids in ameliorating a range of disease states, including cardiovascular disease, Alzheimer’s and Parkinson’s disease and other neurodegenerative disorders, and cancer. The research presented in this volume provides a reliable starting point for further inquiry and experimentation. Vitamin D: Oxidative Stress, Immunity, and Aging (Oxidative Stress and Disease) Vitamin D
insufficiency/deficiency is a worldwide, public health
problem in both developed and developing countries.
Rickets among infants has reemerged. Low levels of
vitamin D are associated with increased risk and
mortality from cancer. At the same time, the beneficial
effects of vitamin D on a host of conditions have
recently been discovered. Focusing on areas not
extensively covered in other comparable books, Vitamin
D: Oxidative Stress, Immunity, and Aging highlights the
most recent research findings on the impact of this
nutrient in oxidative stress,
immunity, and aging.
A state-of-the-art compilation of essential information, this book explores: Vitamin D and its genomic and nongenomic effects, the role of therapeutic analogs in treating disease, and the production of vitamin D by the body The role vitamin D plays in modulating oxidative stress―with emphasis on cancer, stress-mediated diseases, photo-protection of the skin, and energy metabolism Beneficial effects of vitamin D in regulating the immune response and its importance in protecting against autoimmune, infectious, and inflammatory diseases The role vitamin D plays in the regulation of the aging process―including aspects of oxidative stress, senescence, and mortality, as well as its role in protection against cardiovascular disease and nervous system disorders This book represents an important contribution toward understanding the mechanisms by which vitamin D promotes health, increasing awareness of the importance that vitamin D plays during development, at birth, and throughout the aging process. It is a valuable reference for researchers in academia, nutrition, medicine, and industry. The role of free radicals
and oxidative stress in neurological
disorders has only recently been recognized, leaving
clinical neurologists to seek in vain for information on
the subject even in major textbooks. What published
information there is may consist of brief reminders of
the possible association of superoxidase dismutase with
familial amyotrophic lateral sclerosis and nitrous oxide
with migraine. With luck they may also find information
on the purported role of free radicals in the
pathogenesis of traumatic brain injury. Oxidative Stress
and Free Radical Damage in Neurology sets the record
straight, focusing on clinical and research issues
regarding the interplay of free radicals and the human
nervous system. Crucially, the chapters cover numerous
antioxidants and their possible therapeutic role in
neurological disorders. Key illnesses such as epilepsy,
multiple sclerosis and Parkinson’s are analyzed, and
chapters also examine more general issues such as the
link between free radicals and inflammation of the
central nervous system. Clinicians and laboratory
researchers alike will find that this book augments
their understanding not only of the widespread
involvement of free radicals in the central nervous
system but also of some uncertainties surrounding
whether free radical damage in neurology plays a primary
or secondary role.
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