Mitochondria |
With information for
patients and practitioners on optimizing mitochondrial
function for greater health and longevity
Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. The book begins with my
own health journey through mitochondrial
fatigue and how I overcame it with the functional
medicine approach to diagnosis and treatment. The first
two chapters discuss the basic science of the mitochondria
and their involvement in cell defense, energy
production, aging, and cancer. The following chapters
deals with the avoidance of chemicals, pesticides, and
toxins that poison the mitochondria, food to nourish
them, supplements, and hormetic lifestyle changes. The
next chapter details the functional medicine approach to
patient's symptoms using lab testing to arrive at the
diagnosis and treatment. The book concludes with a
summary of actionable items that the reader can do at
home.
If you suffer from chronic fatigue, excess fat that you can't lose, brain fog, or any number of symptoms, the answer might just lie deep in your cell called mitochondria. They are responsible to make energy called ATP for the cell to function. If they sense danger to the cell and to themselves, they will shut down ATP production and go into cell defense mode, resulting in generalized dysfunction of the most active cells like the muscles and brain. You can now reverse this process using a validated method by the Mayo Clinic. Dr. Chang has personally gone through a health journey of mitochondrial dysfunction and fatigue and by applying the methods in the book, he has fully recovered. Mitochondria: From Physiology to Pathology Mitochondria
play an increasingly central role in the context of cellular
physiology. These organelles possess their own genome (mtDNA),
which is functionally coordinated with the nuclear
genome. Mitochondrial gene expression is mediated by
molecular processes (replication, transcription,
translation, and assembly of respiratory chain
complexes) that all take place within the mitochondria.
Several aspects of mtDNA expression have already been
well characterized, but many more either are under
debate or have yet to be discovered.
Understanding the molecular processes occurring in mitochondria also has clinical relevance. Dysfunctions affecting these important metabolic 'hubs' are associated with a whole range of severe disorders, known as mitochondrial diseases. In recent years, significant progress has been made to understand the pathogenic mechanisms underlying mitochondrial dysfunction; however, to date, mitochondrial diseases are complex genetic disorders without any effective therapy. Current therapeutic strategies and clinical trials are aimed at mitigating clinical manifestations and slowing the disease progression to improve the quality of life of patients. The goal of the Special Issue 'Mitochondria: from Physiology to Pathology' published in Life (ISSN: 2075-1729) was to collect research and review articles covering the physiological and pathological aspects related to mtDNA maintenance and gene expression, mitochondrial biogenesis, protein import, organelle metabolism, and quality control. Ever wonder why
toddlers and preschoolers run around with endless
energy, and you’re ready to fall asleep just watching
them? Finally, Dr. Susanne Bennett, DC, CCSP, has the
answer! And it all has to do with the mighty
mitochondria—that subcellular organelle
that is responsible for your body’s energy production.
Through Mighty Mito, Dr. Susanne explains why we lose energy as we get older and how each one of us can regain that energy by providing what our mitochondria thrive on. Healthy mitochondria equal better energy production in our cells. Better energy production equals more energy—and you’ll feel years, or even decades, younger. Mighty Mito contains step-by-step instructions on what mitochondria need to be healthy, including diet, exercise, and your environment. Power up your mitochondria for boundless energy, laser sharp mental focus, and a powerful vibrant body—it’s that simple. Mitochondria in Health and Diseases Mitochondria
are subcellular organelles evolved by the
endosymbiosis of bacteria with eukaryotic cells. They
are the main source of ATP in the cell and engaged in
other aspects of cell metabolism and cell
function, including the regulation of ion
homeostasis, cell growth, redox status, and cell
signaling. Due to their central role in cell life and
death, mitochondria are also involved in the
pathogenesis and progression of human
diseases/conditions, including neurodegenerative and
cardiovascular disorders, cancer, diabetes,
inflammation, and aging. However, despite the
increasing number of studies, precise mechanisms
whereby mitochondria are involved in the regulation of
basic physiological functions, as well as their role
in the cell under pathophysiological conditions,
remain unknown. A lack of in-depth knowledge of the
regulatory mechanisms of mitochondrial
metabolism and function, as well as
interplay between the factors that transform the organelle
from its role in pro-survival to pro-death, have
hindered the development of new mitochondria-targeted
pharmacological and conditional approaches for the
treatment of human diseases. This book highlights the
latest achievements in elucidating the role of
mitochondria under physiological conditions, in
various cell/animal models of human diseases, and in
patients.
This book is the
eagerly awaited second edition of the best-selling
Mitochondria, a book widely acknowledged as the
first modern, truly comprehensive authored work on
the important, scientifically fundamental topic of
the cellular organelles known as
mitochondria.
This new edition brings readers completely up to date on the many significant findings that have occurred in the eight years since the book was first published. As in that seminal first edition, the second edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The new edition provides thorough updates of all literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis-à-vis a broad range of issues in cellular and molecular biology. The book includes detailed descriptions of current and developing technologies around mitochondrial research and discovery, and highlights subjects that are growing, such as the use of proteomics. This book is an invaluable resource for all geneticists, biologists, and educators in life sciences. It is also of interest for advanced students in genetics and molecular biology. What are the functions
of mitochondria in the human body? Why might
they stop working properly and what can happen as a
result? How can personalized nutrition
help to optimize mitochondrial function
and prevent or address chronic conditions?
This innovative book explores the incredibly complex biochemical roles of mitochondria in health and disease. When healthy, mitochondria provide us with ninety percent of our body's energy. When unhealthy, this can lead to many chronic and degenerative conditions including cancer and Alzheimer's disease. This guide helps practitioners to identify the mitochondrial dysfunction underlying a wide range of health complaints, and provides inspiration about relevant and emerging mitochondria-supportive dietary regimes and nutrients to explore within the model of personalized nutrition. Your Mitochondria: Key to Health and Longevity The powerhouses of the
cell, mitochondria take in nutrients,
break them down, and create energy-rich molecules that
drive cellular processors in the body. Knowing how
your mitochondria work is essential to your
well-being. This book takes a deep dive into the
relationship between mitochondrial health,
overall health, and aging. Dr. Warren Cargal, a
multi-book author, board-certified Acupuncturist, and
an expert on Chinese medicine with over 20 years of
experience will show you:
How unhealthy mitochondria can cause cardiovascular diseases, cardiometabolic syndrome, neurodegenerative diseases, arthritis, cancer, and aging effects on the skin, eyes, and muscles. How to take control of and increase your energy reserves to make them efficient. How to restore your mitochondria so you can combat increased body fat and reduced lean muscle mass, inefficient metabolism, increased low-grade inflammation, inadequate performance, accelerating aging, and, unfortunately for some, premature death. Your Mitochondria: Key to Health and Longevity is a must-read for anyone who wants to live an abundant and healthy life.
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