Free Radicals |
Free Radicals in Biology and Medicine Free Radicals in Biology
and Medicine has become a classic text in the field of
free radical and antioxidant research. Now in its fifth
edition, the book has been comprehensively rewritten and
updated whilst maintaining the clarity of its
predecessors. Two new chapters discuss 'in vivo' and
'dietary' antioxidants, the first emphasising the role of
peroxiredoxins and integrated defence mechanisms which
allow useful roles for ROS, and the second containing new
information on the role of fruits, vegetables, and
vitamins in health and disease. This new edition also
contains expanded coverage of the mechanisms of oxidative
damage to lipids, DNA, and proteins (and the repair of
such damage), and the roles played by reactive species in
signal transduction, cell survival, death, human
reproduction, defence mechanisms of animals and plants
against pathogens, and other important biological events.
The methodologies available to measure reactive species
and oxidative damage (and their potential pitfalls) have
been fully updated, as have the topics of phagocyte ROS
production, NADPH oxidase enzymes, and toxicology. There
is a detailed and critical evaluation of the role of free
radicals and other reactive species in human diseases,
especially cancer, cardiovascular, chronic inflammatory
and neurodegenerative diseases. New aspects of ageing are
discussed in the context of the free radical theory of
ageing.
This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences. Free Radicals in Human Health and Disease The role of oxidative
stress in human disease has become an area of intense
interest. Free radicals, a normal product of metabolism,
exist in all aerobic cells in balance with biochemical
antioxidants. Environmental stress increases the levels
of free radicals drastically, thereby disturbing the
equilibrium between free radical production and the
antioxidant capability causing oxidative stress. Over
the years, ROS has been implicated in the pathologies of
various diseases like cancer, neurological disorder,
cardiovascular diseases rheumatoid arthritis, diabetes
etc. This book provides an in depth critical
state-of-art reviews from established investigators on
free radicals, ROS associated pathogenesis of human
diseases, biomarkers of oxidative damage, antioxidants,
phytonutrients and other related health concerns of
modern society.
The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress. This books reviews free
radicals and health. Chapter One discusses the role of
radicals in the impact of phenols on health and the
environment. Chapter Two describes the very recent
development of new synthetic phenol-containing polymers
as effective free radical scavengers in aqueous
environments, such as a phenolic resin (particularly
novolac resin) grafted with hydrophilic poly(ethylene
glycol) (PEG) by click chemistry. Chapter Three reviews
the possible applications of radon therapy in veterinary
care for oxidative stress-induced kidney damage. Chapter
Four examines how melatonin could be taken into account
as a drug with uses for cancer treatment in combination
with the current chemotherapeutic drugs, reducing the
dose of these agents and the toxicity for the patient.
Chapter Five studies oxidative stress in rheumatoid
arthritis. Chapter Six presents facts that review how
the health benefits of many phytochemicals in natural
beverages may be the consequence of hormetic effect and
cross-resistance from the auto-oxidation of antioxidants
leading to the formation of H2O2, which activates one or
more adaptive stress response pathways.
Antioxidants Versus Free Radicals: A guide to a Healthy Long Life The purpose of this book
is to educate us on how diseases develop, learn the
benefits and consequences of the decision we make of the
food we eat and the lifestyle we choose in relation to
our health and longevity.
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Free Radicals and Health